منابع مشابه
Unveiling astrocytic control of cerebral blood flow with optogenetics
Cortical neural activities lead to changes in the cerebral blood flow (CBF), which involves astrocytic control of cerebrovascular tone. However, the manner in which astrocytic activity specifically leads to vasodilation or vasoconstriction is difficult to determine. Here, cortical astrocytes genetically expressing a light-sensitive cation channel, channelrhodopsin-2 (ChR2), were transcranially ...
متن کاملParasympathetic cholinergic control of cerebral blood flow in dogs.
We studied the effects of cholinergic receptor activation on cerebral blood flow in dogs anesthetized with chloralose. Continuous measurements of cerebral blood flow, arterial and cerebral spinal fluid pressure, heart rate, and respiratory carbon dioxide tension were made during parasympathetic nerve stimulation and during intraarterial infusion of acetylcholine. Multiple samples of arterial an...
متن کاملSympathetic control of cerebral blood flow in dogs.
The effect of sympathetic stimulation on cerebral blood flow was investigated in dogs anesthetized with chloralose. A preparation has been developed for the moment-to-moment measurement of cerebral venous outflow with an electromagnetic flow transducer. The brain's arterial supply was left undisturbed. The sympathetic innervation of the cerebral vessels was stimulated at the stellate ganglion (...
متن کاملNeurogenic control of cerebral blood flow in the baboon.
Cerebral chemical vasomotor reactivity and autoregulation were tested in normal baboons before and after the intravenous or intravertebral infusion of atropine sulfate (0.02 mg/kg). Atropine did not appreciably effect autoregulatory response, but intravertebral injection suppressed the increase of cerebral blood flow (CBF) by inhalation of 5% CO2 and enhanced the decrease of CEF induced by hype...
متن کاملA physiological model of cerebral blood flow control.
The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic biochemistry, and a model of the functioning of vascular smooth muscle (VSM) into a single model. This represents a first attempt to understand how the numerous different feedback pathways by which cereb...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2021
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2021.02.023